British Air Force Typhoon FGR4s have operated alongside French warplanes in a combined operation targeting an underground arms cache in Syrian territory operated by the IS group, according to the UK Ministry of Defence.
The site, identified by intelligence, was believed to be housing weapons and explosive materials, the announcement noted, and was situated in hills just north of the ancient city of Palmyra in Syria's central region.
"Our aircraft employed Paveway IV guided bombs to target a number of entry passages providing entry to the facility... preliminary assessments suggest the strike was effective," the ministry announced.
There was no indication of any civilian casualties in the operation on Saturday evening and each participating jet returned to base without incident, the defence officials confirmed.
The British jets were backed up by a Voyager refuelling tanker.
The Islamic State group - alternatively referred to as Daesh - enforced jihadist rule over large swathes of Syria and Iraq until 2019.
"This action underscores British leadership, and resolve to work closely with allied nations, to eradicate any revival of IS and their dangerous and violent ideologies in the area," the British Defence Secretary the minister said.
UK warplanes have conducted surveillance missions over Syria to "forestall any efforts to regroup" of Islamic State subsequent to its military defeat at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I extend gratitude to all the members of British forces involved in this operation for their skill and their courage," Healey said. "They were part of a great many UK service members on duty over Christmas and New Year. This action, to remove militants who endanger our security, highlights how our armed forces are ready to step up, continuously, keeping Britain secure domestically and influential overseas."
Last December, the American forces carried out what it termed a "large-scale strike" against IS targets in Syria, after an assault claimed the lives of two American soldiers and a civilian interpreter in Palmyra.
The United Nations says Islamic State still boasts roughly 5-7 thousand militants in Syria and Iraq.